International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
The opioid epidemic: crisis and solutions
P Skolnick - Annual review of pharmacology and toxicology, 2018 - annualreviews.org
The widespread abuse of prescription opioids and a dramatic increase in the availability of
illicit opioids have created what is commonly referred to as the opioid epidemic. The …
illicit opioids have created what is commonly referred to as the opioid epidemic. The …
Modulating the neuromodulators: dopamine, serotonin, and the endocannabinoid system
Dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and endocannabinoids (ECs) are
key neuromodulators involved in many aspects of motivated behavior, including reward …
key neuromodulators involved in many aspects of motivated behavior, including reward …
Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder
LL Howell, KA Cunningham - Pharmacological reviews, 2015 - ASPET
Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …
disorder with significant morbidity. Major advances have been made in delineating …
Allosteric modulation of class A GPCRs: targets, agents, and emerging concepts
EA Wold, J Chen, KA Cunningham… - Journal of medicinal …, 2018 - ACS Publications
G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications
P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …
and dopamine (DA) interactions play a key role in normal and abnormal behavior …
Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5‐HT levels in nucleus accumbens of awake rats
J Kehr, F Ichinose, S Yoshitake, M Goiny… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE The designer drug 1‐(4‐methylphenyl)‐2‐
methylaminopropan‐1‐one (4‐methylmethcathinone, mephedrone) is reported to possess …
methylaminopropan‐1‐one (4‐methylmethcathinone, mephedrone) is reported to possess …
Developments in harmine pharmacology—Implications for ayahuasca use and drug-dependence treatment
DI Brierley, C Davidson - Progress in neuro-psychopharmacology and …, 2012 - Elsevier
Ayahuasca is a hallucinogenic botanical mixture originating in the Amazon area where it is
used ritually, but is now being taken globally. The 2 main constituents of ayahuasca are N, N …
used ritually, but is now being taken globally. The 2 main constituents of ayahuasca are N, N …
5-HT2C receptors in psychiatric disorders: a review
HT2Rs have a different genomic organization from other 5-HT2Rs. 5HT2CR undergoes post-
transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post …
transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post …
New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders
G Di Giovanni, P De Deurwaerdère - Pharmacology & therapeutics, 2016 - Elsevier
Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …