[HTML][HTML] Chromatin remodeling BAF (SWI/SNF) complexes in neural development and disorders
G Sokpor, Y Xie, J Rosenbusch, T Tuoc - Frontiers in molecular …, 2017 - frontiersin.org
The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …
[HTML][HTML] Vulnerabilities of mutant SWI/SNF complexes in cancer
KC Helming, X Wang, CWM Roberts - Cancer cell, 2014 - cell.com
Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers
are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding …
are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding …
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …
Mammalian SWI/SNF continuously restores local accessibility to chromatin
M Iurlaro, MB Stadler, F Masoni, Z Jagani, GG Galli… - Nature …, 2021 - nature.com
Chromatin accessibility is a hallmark of regulatory regions, entails transcription factor (TF)
binding and requires nucleosomal reorganization. However, it remains unclear how …
binding and requires nucleosomal reorganization. However, it remains unclear how …
[HTML][HTML] The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers
Genes encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are
collectively altered in over 20% of human malignancies, but the mechanisms by which these …
collectively altered in over 20% of human malignancies, but the mechanisms by which these …
Annotation of functional variation in personal genomes using RegulomeDB
As the sequencing of healthy and disease genomes becomes more commonplace, detailed
annotation provides interpretation for individual variation responsible for normal and …
annotation provides interpretation for individual variation responsible for normal and …
[HTML][HTML] Latent enhancers activated by stimulation in differentiated cells
According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-specific …
repertoire is completely established and maintained by cooperatively acting lineage-specific …
[HTML][HTML] The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
Pioneer transcription factors recognise and bind their target sequences in inaccessible
chromatin to establish new transcriptional networks throughout development and cellular …
chromatin to establish new transcriptional networks throughout development and cellular …
[HTML][HTML] Profiling of pluripotency factors in single cells and early embryos
Cell fate decisions are governed by sequence-specific transcription factors (TFs) that act in
small populations of cells within developing embryos. To understand their functions in vivo, it …
small populations of cells within developing embryos. To understand their functions in vivo, it …
[HTML][HTML] A UTX-MLL4-p300 transcriptional regulatory network coordinately shapes active enhancer landscapes for eliciting transcription
Enhancer activation is a critical step for gene activation. Here we report an epigenetic
crosstalk at enhancers between the UTX (H3K27 demethylase)-MLL4 (H3K4 …
crosstalk at enhancers between the UTX (H3K27 demethylase)-MLL4 (H3K4 …