Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Simple Summary Osteosarcoma (OS), the most common primary bone tumor, mainly affects
children and adolescents. Unfortunately, in some cases, the absence of response to …

Members of the family of B9 vitamins are commonly known as folates. They are derived
entirely from dietary sources and are key one-carbon donors required for de novo nucleotide …

In autoimmune diseases and allografts, however, MTX dosage is usually in the range of 7–
15 mgrweek, given as a single dose or in two or three divided doses 12 h apart, orally or by …

This review attempts to provide a comprehensive overview of the biology of the
physiologically and pharmacologically important transport system termed the “reduced folate …

As the cure rates for haematological malignancies have improved, the exploration of the
balance between efficacy and side effects has become a major research target. The …

This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT
was identified in 2006 as the primary transporter for intestinal absorption of dietary folates …

OBJECTIVES:: To provide an update of the current knowledge of the mechanism ofaction of
low-dose methotrexate (MTX) in the treatment of patients with rheumatoid arthritis (RA), with …

Methotrexate (MTX), one of the earliest cancer chemotherapy agents, continues to be used
extensively in the treatment of leukemia and a variety of other tumors. The efficacy of this …

Membrane transporters play important roles in mediating chemosensitivity and-resistance of
tumor cells. ABC transporters, such as ABCB1/MDR1, ABCC1/MRP1 and ABCG2/BCRP, are …