RNA in cancer
GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
[HTML][HTML] Targeting PI3K in cancer: mechanisms and advances in clinical trials
Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …
signaling is one of the most important intracellular pathways, which can be considered as a …
[HTML][HTML] The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
[HTML][HTML] PI3K inhibitors in cancer: clinical implications and adverse effects
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
[HTML][HTML] Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
TP63, SOX2, and KLF5 establish a core regulatory circuitry that controls epigenetic and transcription patterns in esophageal squamous cell carcinoma cell lines
Background & Aims We investigated the transcriptome of esophageal squamous cell
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …
The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential
X Meng, QY Lou, WY Yang, YR Wang… - Cancer …, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …
[HTML][HTML] Long non-coding RNAs regulate drug resistance in cancer
Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of
cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various …
cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various …
LncSEA: a platform for long non-coding RNA related sets and enrichment analysis
J Chen, J Zhang, Y Gao, Y Li, C Feng… - Nucleic acids …, 2021 - academic.oup.com
Long non-coding RNAs (lncRNAs) have been proven to play important roles in
transcriptional processes and various biological functions. Establishing a comprehensive …
transcriptional processes and various biological functions. Establishing a comprehensive …
[HTML][HTML] The chromatin-associated RNAs in gene regulation and cancer
J Tang, X Wang, D Xiao, S Liu, Y Tao - Molecular Cancer, 2023 - Springer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …