Coumarin hybrids have been designed and synthesized as an important new strategy in the
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …

To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin
are utilized, and notably, the emergence of various side effects of existing drugs used for …

Thiazole, a five-membered heterocyclic compound constitutes the skeleton of various
commercially marketed drug candidates and the heart-core in a diverse range of entities of …

The exhaustive exploration of the conventional synthetic approaches for the synthesis of
nitrogen and sulphur containing heterocyclic moieties has diverted the attention of …

Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is
reabsorbed or deactivated by acetylcholinesterase (AChE). Studies on Alzheimer's disease …

The synthesis and biological assessment of novel multi-functionalized pyrrolidine-containing
benzenesulfonamides were reported along with their antimicrobial, antifungal, CAs …

The transforming growth factor-β (TGF-β), in which overexpression has been associated with
various diseases, has become an attractive molecular target for the treatment of cancers …

A series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an
imidazole moiety has been prepared and their various biological activities are evaluated …

In this article, we present an efficient, one-pot regioselective approach towards the synthesis
of 2-aryl/hetaryl-4-methyl-5-acylthiazoles obtained during the reaction of α-bromo-1, 3 …

A new one-pot four-component preparation of polysubstituted thiazoles by a cascade
Ugi/Wittig cyclization has been developed. The four-component reactions of the odorless …