The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

The incidence and prevalence of cardiac diseases, which are the main cause of death
worldwide, are likely to increase because of population ageing. Prevailing theories about …

Doxorubicin is an effective anti-tumor agent with a cumulative dose-dependent
cardiotoxicity. In addition to its principal toxic mechanisms involving iron and redox …

The ubiquitin-proteasome system (UPS) and autophagy are the two major intracellular
protein quality control (PQC) pathways that are responsible for cellular proteostasis …

The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …

In the cell, the proteasome and lysosomes represent the most important proteolytic
machineries, responsible for the protein degradation in the ubiquitin–proteasome system …

Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived
proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy …

Autophagy is a catabolic pathway for bulk turnover of long-lived proteins and organelles via
lysosomal degradation. Growing evidence reveals that autophagy is involved in the …

The heart is highly sensitive to the aging process. In the elderly, the heart tends to become
hypertrophic and fibrotic. Stiffness increases with ensuing systolic and diastolic dysfunction …