▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …

▪ Abstract Natural killer cells are likely to play an important role in the host defenses because
they kill virally infected or tumor cells but spare normal self-cells. The molecular mechanism …

Human cytomegalovirus (HCMV) down-regulates expression of MHC class I products by
selective proteolysis. A single HCMV gene, US11, which encodes an endoplasmic reticulum …

HLA expression is frequently altered in tumours compared to the tissue from which they
originate. Given the central role of MHC products in the restriction of T-cell recognition …

Herpes simplex virus (HSV) infection of human fibroblasts rapidly renders the cells resistant
to lysis by HSV-specific CDS+ cytotoxic T lymphocytes (CTLs), which normally recognize cell …

The human cytomegalovirus (HCMV) early glycoprotein products of the US11 and US2 open
reading frames cause increased turnover of major histocompatibility complex (MHC) class I …

Although the role of natural killer (NK) cells in defense against certain viral infections has
been appreciated for a number of years, characterization of the virus-induced endogenous …

CD8+ T cells are the main effector cells for the immune control of cytomegaloviruses. To
subvert this control, human and mouse cytomegaloviruses each encode a set of immune …

The human cytomegalovirus (HCMV) genomic unique short (US) region encodes a family of
homologous genes essential for the inhibition of major histocompatibility complex (MHC) …

Malignant tumor cells can escape CD8+ cytotoxic T cell killing by downregulating class I
major histocompatibility complex (MHC) expression. Stable class I MHC surface expression …