Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

Transforming growth factor-β (TGF-β) potently inhibits cell cycle progression at the G1
phase,. Smad3 has a key function in mediating the TGF-β growth-inhibitory response. Here …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

During transcription, RNA polymerase (Pol) II synthesizes eukaryotic messenger RNA.
Transcription is coupled to RNA processing by the carboxy-terminal domain (CTD) of Pol II …

The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient
termination. A key player in this process is the cleavage and polyadenylation (CPA) factor …

The C-terminal domain (CTD) of RNA polymerase II (Pol II) integrates nuclear events by
binding proteins involved in mRNA biogenesis. CTD-binding proteins recognize a specific …