Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

With the rapid advance of single-cell sequencing technology, cell heterogeneity in various
biological processes was dissected at different omics levels. However, single-cell mono …

Phase separation, a biophysical segregation of subcellular milieus referred as condensates,
is known to regulate transcription, but its impacts on physiological processes are less clear …

The last decade has seen a robust increase in various types of novel RNA molecules and
their complexity in gene regulation. RNA molecules play a critical role in cellular events by …

The hybrid chain reaction (HCR), an isothermal and enzyme-free amplification strategy, has
found extensive use in fluorescent in situ hybridization (FISH) assays. However, the existing …

The visualization of multiple gene expressions in well-preserved tissues is crucial for the
elucidation of physiological and pathological processes. In situ hybridization chain reaction …

Full-length mRNAs transfer between adjacent mammalian cells via direct cell-to-cell
connections called tunneling nanotubes (TNTs). However, the extent of mRNA transfer at the …

Dynamic tracking of the localization of RNA molecules (nucleus and/or cytoplasm) and RNA
splicing in living cells plays an important role in understanding their functions. However, a …

It was already suggested in the early '70's that RNA molecules might transfer between
mammalian cells in culture. Yet, more direct evidence for RNA transfer in animal and plant …

Spatial transcriptome technology acquires gene expression profiles while retaining spatial
location information, it displays the gene expression properties of cells in situ. Through the …