Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the
most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and …

Patients suffering from iron overload can experience serious complications. In such patients,
various organs, such as endocrine glands and liver, can be damaged. Although iron is a …

Patients with β-thalassemia major (BTM) require regular blood transfusions, supported by
appropriate iron chelation therapy (ICT), throughout their life. β-thalassemia is a global …

β-Thalassemias Defective synthesis of the β-globin chain causes recessively inherited
disorders characterized by inadequate hemoglobin production and chronic anemia …

Pese a los grandes avances de nuestros conocimientos sobre la patología molecular, la
fisiopatología y el control y manejo de las hemoglobinopatías hereditarias, miles de …

Aims To develop and validate a non-invasive method for measuring myocardial iron in order
to allow diagnosis and treatment before overt cardiomyopathy and failure develops …

BACKGROUND AND OBJECTIVES: Seven Italian centers reported data on survival, causes
of death and appearance of complications in patients with thalassemia major. The …

This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

(BM) expansion, permit normal development throughout childhood, and extend survival. 1 In
parallel, transfusions re- Early studies of the use of neocytes, or young RBCs, sult in a …

Thalassaemia is one of the most common genetic diseases worldwide, with at least 60 000
severely affected individuals born every year. Individuals originating from tropical and …