The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an
alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes …

Background: Non–vitamin K oral anticoagulants (NOACs) do not require routine laboratory
monitoring. However, laboratory measurement may be desirable in special situations and …

The most commonly prescribed oral anticoagulants worldwide are the vitamin K antagonists
(VKAs) such as warfarin. Factors affecting the pharmacokinetics of VKAs are important …

Background: Gastrointestinal (GI) bleeding is a common complication of oral
anticoagulation. Objectives: This study evaluated GI bleeding in patients who received at …

Learning Objectives Cite the current indications, basic clinical pharmacology, and rationale
for development of the new oral anticoagulants. Explain the potential risk for drug-drug …

Vitamin K antagonists (VKAs) such as warfarin are the most commonly prescribed oral
anticoagulants worldwide. However, factors affecting the pharmacokinetics of VKAs, such as …

Direct oral anticoagulants (DOAC) have shown an upward prescribing trend in recent years
due to favorable pharmacokinetics and pharmacodynamics without requirement for routine …

Studies comparing gender-specific outcomes in patients with atrial fibrillation (AF) have
reported conflicting results. Gender differences in cerebrovascular accident/systemic …

The new oral anticoagulants (NOACs), which include dabigatran, rivaroxaban, apixaban,
and edoxaban, are poised to replace warfarin for treatment of the majority of patients with …

The use of warfarin, the most commonly prescribed oral anticoagulant, is being questioned
by clinicians worldwide due to warfarin several limitations (a limited therapeutic window and …