Unlocking the potential of mesoporous silica nanoparticles in breast cancer treatment

R Thapa, H Ali, O Afzal, AA Bhat, WH Almalki… - Journal of Nanoparticle …, 2023 - Springer
Breast cancer is the most common cancer among women and is typically managed through
surgery, radiation therapy, and chemotherapy. However, chemotherapy drugs often lack …

[HTML][HTML] Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

KR Gajbhiye, R Salve, M Narwade, A Sheikh… - Molecular Cancer, 2023 - Springer
Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug
therapy. But presently, detailed investigations have revealed their flaws as drug delivery …

[HTML][HTML] Application of aptamer-drug delivery system in the therapy of breast cancer

R Fan, X Tao, X Zhai, Y Zhu, Y Li, Y Chen… - Biomedicine & …, 2023 - Elsevier
Despite significant treatment advances, breast cancer remains the leading cause of cancer
death in women. From the current treatment situation, in addition to developing …

[HTML][HTML] Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery

M Narwade, A Shaikh, KR Gajbhiye, P Kesharwani… - Biomaterials …, 2023 - Springer
The non-specificity of standard anticancer therapies has profound detrimental
consequences in clinical treatment. Therapeutic specificity can be precisely achieved using …

Aptamers against cancer drug resistance: Small fighters switching tactics in the face of defeat

M Sanati, AR Afshari, SS Ahmadi, P Kesharwani… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Discovering novel cancer therapies has attracted extreme interest in the last decade. In this
regard, multidrug resistance (MDR) to chemotherapies is a key challenge in cancer …

A comprehensive review of small interfering RNAs (siRNAs): mechanism, therapeutic targets, and delivery strategies for cancer therapy

J Zhang, B Chen, C Gan, H Sun, J Zhang… - International Journal of …, 2023 - Taylor & Francis
Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …

[HTML][HTML] Recent advances in mesoporous silica nanoparticles delivering siRNA for cancer treatment

X Xie, T Yue, W Gu, WY Cheng, L He, WY Ren, F Li… - Pharmaceutics, 2023 - mdpi.com
Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer.
However, the curative effect of siRNA is severely constrained by low serum stability and cell …

Nanocarriers for delivering nucleic acids and chemotherapeutic agents as combinational approach: Challenges, clinical progress, and unmet needs

M Rahman, O Afzal, SNMN Ullah… - Journal of Drug Delivery …, 2023 - Elsevier
Cancer is the second leading cause of death after heart disease. It forms clusters of
immature cells, spreads through metastasis, and invades normal tissue. Chemotherapeutic …

TfR Aptamer-functionalized MSNs for enhancing targeted cellular uptake and therapy of cancer cells

J Zhang, J Shang, X Tang, X Xu - ACS omega, 2023 - ACS Publications
Mesoporous silica nanoparticles (MSNs), as novel nanocarriers for drug delivery in cancer
treatment, have attracted widespread concern because of their rich pore structure, large …

Stimuli‐Responsive Aptamer‐Drug Conjugates for Targeted Drug Delivery and Controlled Drug Release

S Zhu, H Gao, W Li, X He, P Jiang, F Xu… - Advanced …, 2024 - Wiley Online Library
Chemotherapy has been widely used for cancer therapy but with unsatisfied efficacy, mainly
due to the inefficient delivery of anticancer agents. Among the critical “five steps” drug …