Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …

The intestine has a major role in the digestion and absorption of nutrients, and gut barrier is
the first defense line against harmful pathogens. Alteration of the intestinal barrier is …

Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and
accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in …

The importance of the kynurenine pathway in normal immune system function has led to an
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …

Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

Recent advances in amino acid metabolism have revealed that targeting amino acid
metabolic enzymes in cancer therapy is a promising strategy for the development of novel …

Background: The kynurenine pathway (KP) is the major catabolic pathway for tryptophan
degradation. The KP plays an important role as the sole de novo nicotinamide adenine …