Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

In this review, we address recent advances made in pathway engineering, directed
evolution, and systems/synthetic biology approaches employed in the production and …

Metabolic engineering has been enabling development of high performance microbial
strains for the efficient production of natural and non-natural compounds from renewable …

Over 9,000 flavonoid compounds have been found in various plants, comprising one of the
largest families of natural products. Flavonoids are an essential factor in plant interactions …

Plant flavonoids are secondary metabolites containing a benzo-γ-pyrone structure, which
are widely present in plants and have a variety of physiological and pharmacological …

Corynebacterium glutamicum is an important organism in industrial biotechnology for the
microbial production of bulk chemicals, in particular amino acids. However, until now activity …

Malonyl-CoA is the building block for fatty acid biosynthesis and also a precursor to various
pharmaceutically and industrially valuable molecules, such as polyketides and biopolymers …

Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

Pathway balancing is a critical and common challenge for microbial biosynthesis using
metabolic engineering approaches. Non-linear biosynthetic pathways, such as diverging …

Plant flavonoid polyphenols continue to find increasing pharmaceutical and nutraceutical
applications; however their isolation, especially of pure compounds, from plant material …