The Antidepressant Sertraline Affects Cell Signaling and Metabolism in Trichophyton rubrum

FM Galvão-Rocha, CHL Rocha, MP Martins… - Journal of Fungi, 2023 - mdpi.com
The dermatophyte Trichophyton rubrum is responsible for most human cutaneous infections.
Its treatment is complex, mainly because there are only a few structural classes of fungal …

The StuA Transcription Factor and Alternative Splicing Mechanisms Drive the Levels of MAPK Hog1 Transcripts in the Dermatophyte Trichophyton rubrum

L Martins-Santana, MF Petrucelli, PR Sanches… - Mycopathologia, 2024 - Springer
Trichophyton rubrum is a human fungal pathogen that causes dermatophytosis, an infection
that affects keratinized tissues. Integrated molecular signals coordinate mechanisms that …

The Transcription Factor StuA Regulates the Glyoxylate Cycle in the Dermatophyte Trichophyton rubrum under Carbon Starvation

MF Petrucelli, L Martins-Santana, PR Sanches… - International Journal of …, 2023 - mdpi.com
Trichophyton rubrum is the primary causative agent of dermatophytosis worldwide. This
fungus colonizes keratinized tissues and uses keratin as a nutritional source during …

Molecular Signaling and Metabolic Responses during the Interaction between Human Keratinocytes (HaCaT) and the Dermatophyte Trichophyton rubrum

MF Petrucelli, L Martins-Santana, A Rossi… - Journal of Fungi, 2024 - mdpi.com
Trichophyton rubrum is the leading causative agent of dermatophytosis worldwide.
Keratinocytes are the first line of defense that drives an immune response against fungal …

Biophysical Characterization of the C-Terminal Tail of T. rubrum PacC Reveals an Inherent Intrinsically Disordered Structure with pH-Induced Structural Plasticity

SS Dey, R Chakraborty, B Taneja - ACS omega, 2022 - ACS Publications
PacC is a key transcriptional regulator of human pathogenic fungus Trichophyton rubrum
with pivotal roles in pH homeostasis and virulence. We report the first biophysical …