[HTML][HTML] MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice

M Aichler, A Walch - Laboratory investigation, 2015 - Elsevier
MALDI Imaging mass spectrometry has entered the field of tissue-based research by
providing unique advantages for analyzing tissue specimen in an unprecedented detail. A …

Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays

TW Powers, BA Neely, Y Shao, H Tang, DA Troyer… - PloS one, 2014 - journals.plos.org
A recently developed matrix-assisted laser desorption/ionization imaging mass spectrometry
(MALDI-IMS) method to spatially profile the location and distribution of multiple N-linked …

Sample preparation for mass spectrometry imaging: small mistakes can lead to big consequences

RJA Goodwin - Journal of proteomics, 2012 - Elsevier
Mass spectrometry imaging (MSI) enables the direct analysis of molecules from the surface
of a wide variety of samples, allowing the multiplex measurement of both abundance and …

Mass spectrometry imaging for drug distribution studies

B Prideaux, M Stoeckli - Journal of proteomics, 2012 - Elsevier
Since its introduction mass spectrometry imaging (MSI) has proven to be a powerful tool for
the localization of molecules in biological tissues. In drug discovery and development …

Absolute quantitative MALDI imaging mass spectrometry: a case of rifampicin in liver tissues

CW Chumbley, ML Reyzer, JL Allen… - Analytical …, 2016 - ACS Publications
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS)
elucidates molecular distributions in thin tissue sections. Absolute pixel-to-pixel quantitation …

Proteomic analysis of formalin-fixed paraffin-embedded tissue by MALDI imaging mass spectrometry

R Casadonte, RM Caprioli - Nature protocols, 2011 - nature.com
Archived formalin-fixed paraffin-embedded (FFPE) tissue collections represent a valuable
informational resource for proteomic studies. Multiple FFPE core biopsies can be assembled …

Mass spectrometry imaging of plant metabolites–principles and possibilities

N Bjarnholt, B Li, J D'Alvise, C Janfelt - Natural product reports, 2014 - pubs.rsc.org
Covering: up to the end of 2013 New mass spectrometry imaging (MSI) techniques are
gaining importance in the analysis of plant metabolite distributions, and significant …

A mimetic tissue model for the quantification of drug distributions by MALDI imaging mass spectrometry

MR Groseclose, S Castellino - Analytical chemistry, 2013 - ACS Publications
The full potential of imaging mass spectrometry (IMS) as a tool in drug development will not
be realized until reliable quantitative information can be integrated with the molecular …

Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review

JG Swales, G Hamm, MR Clench… - International Journal of …, 2019 - Elsevier
Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …