Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Subcellular compartmentalization, cell growth, hormone secretion and neurotransmission
require rapid, targeted, and regulated membrane fusion. Fusion entails extensive lipid …

Despite the recent progress in the field of membrane traffic, the question of how the
specificity of membrane fusion is achieved has yet to be resolved. It has become apparent …

Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

We have identified a 55 kDa protein, named GRASP55 (G olgi rea ssembly s tacking p rotein
of 55 kDa), as a component of the Golgi stacking machinery. GRASP55 is homologous to …

The Golgi apparatus is a central intracellular membrane-bound organelle with key functions
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …

Glycosylation is a ubiquitous modification that occurs on proteins and lipids in all living cells.
Consistent with their high complexity, glycans play crucial biological roles in protein quality …

The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form
a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose …

▪ Abstract Golgi inheritance proceeds via sequential biogenesis and partitioning phases.
Although little is known about Golgi growth and replication (biogenesis), ultrastructural and …

The Golgi apparatus comprises an enormous array of components that generate its unique
architecture and function within cells. Here, we use quantitative fluorescence imaging …