A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer

PA Vieyra-Garcia, P Wolf - Pharmacology & therapeutics, 2021 - Elsevier
UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …

[HTML][HTML] Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways

K Patil, S Kuttikrishnan, AQ Khan, F Ahmad… - Seminars in Cancer …, 2022 - Elsevier
Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative
neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and …

Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

LM Lindahl, A Willerslev-Olsen… - Blood, The Journal …, 2019 - ashpublications.org
It has been proposed that CD4 T-cell responses to Staphylococcus aureus (SA) can
inadvertently enhance neoplastic progression in models of skin cancer and cutaneous T-cell …

Progression of cutaneous T-cell lymphoma after dupilumab: case review of 7 patients

ML Espinosa, MT Nguyen, AS Aguirre… - Journal of the American …, 2020 - jaad.org
The initial improvement may be from the transient blockage of T-helper 2 inflammation with
shifting to a T-helper 1 tumor-suppressive effect via secretion of interferon-; however, the …

Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures

A Herrera, A Cheng, EP Mimitou… - Blood, The Journal …, 2021 - ashpublications.org
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of mature T-cell neoplasms
characterized by the accumulation of clonal malignant CD4+ T cells in the skin. The most …

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

K Rindler, C Jonak, N Alkon, FM Thaler, H Kurz… - Molecular cancer, 2021 - Springer
Background In early-stage mycosis fungoides (MF), the most common primary cutaneous T-
cell lymphoma, limited skin involvement with patches and plaques is associated with a …

[HTML][HTML] Endolysin inhibits skin colonization by patient-derived staphylococcus aureus and Malignant T-cell activation in cutaneous T-cell lymphoma

EMH Pallesen, M Gluud, CK Vadivel, TB Buus… - Journal of Investigative …, 2023 - Elsevier
Staphylococcus aureus is suspected to fuel disease activity in cutaneous T-cell lymphomas.
In this study, we investigate the effect of a recombinant, antibacterial protein, endolysin (XZ …

Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma

M Gluud, EMH Pallesen, TB Buus, LMR Gjerdrum… - Blood, 2023 - ashpublications.org
Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by
the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause …

Single-cell heterogeneity in Sézary syndrome

TB Buus, A Willerslev-Olsen, S Fredholm… - Blood …, 2018 - ashpublications.org
Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma
(CTCL) with a median life expectancy of less than 4 years. Although initial treatment …

[HTML][HTML] Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of cutaneous T-cell lymphoma

MH Fanok, A Sun, LK Fogli, V Narendran… - Journal of investigative …, 2018 - Elsevier
Cutaneous T-cell lymphoma is a heterogeneous group of lymphomas characterized by the
accumulation of malignant T cells in the skin. The molecular and cellular etiology of this …