The complete genomic DNA sequence of the highly attenuated vaccinia strain modified
vaccinia Ankara (MVA) was determined. The genome of MVA is 178 kb in length …

For many viruses, one or two proteins enable cell binding, membrane fusion and entry. The
large number of proteins employed by poxviruses is unprecedented and may be related to …

Monkeypox virus (MPV) belongs to the orthopoxvirus genus of the family Poxviridae, is
endemic in parts of Africa, and causes a human disease that resembles smallpox. The …

Poxviruses comprise a large family of viruses characterized by a large, linear dsDNA
genome, a cytoplasmic site of replication and a complex virion morphology. The most …

Poxviruses comprise a large family of enveloped DNA viruses that infect vertebrates and
invertebrates. Poxviruses, unlike most DNA viruses, replicate in the cytoplasm and encode …

Vaccinia virus (VV) has a complex morphogenetic pathway whose first steps are poorly
characterized. We have studied the early phase of VV assembly, when viral factories and …

The family Poxviridae contains two subfamilies: the Entomopoxvirinae (poxviruses of
insects) and the Chordopoxvirinae (poxviruses of vertebrates). Here we present the first …

The simpler of the two infectious forms of vaccinia virus, the intracellular mature virus (IMV)
is known to infect cells less efficiently than the extracellular enveloped virus (EEV), which is …

The vaccinia virus (VV) A27L gene encodes a 14 kDa protein that is required for the
formation of intracellular enveloped virus (IEV) and, consequently, normal sized plaques …

Vaccinia virus (VV) morphogenesis commences with the formation of lipid crescents that
grow into spherical immature virus (IV) and then infectious intracellular mature virus (IMV) …