mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
Advances in COVID-19 mRNA vaccine development
E Fang, X Liu, M Li, Z Zhang, L Song, B Zhu… - Signal transduction and …, 2022 - nature.com
To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
N Chaudhary, D Weissman… - Nature reviews Drug …, 2021 - nature.com
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …
[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
Lipids and lipid derivatives for RNA delivery
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the
particular administration route and type of drug. Here we report the design of LNPs for the …
particular administration route and type of drug. Here we report the design of LNPs for the …
[HTML][HTML] Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver cell line
M Aldén, F Olofsson Falla, D Yang… - Current issues in …, 2022 - mdpi.com
Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and
BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 …
BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 …
Immunological considerations for COVID-19 vaccine strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
mRNA vaccines in the COVID-19 pandemic and beyond
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus
disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around …
disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around …
Nanomaterial delivery systems for mRNA vaccines
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …
development of lipid nanoparticle delivery systems that not only efficiently express the …