Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …
Advances of amifostine in radiation protection: Administration and delivery
L Ji, P Cui, S Zhou, L Qiu, H Huang… - Molecular …, 2023 - ACS Publications
Amifostine (AMF, also known as WR-2721) is the only approved broad-spectrum small-
molecule radiation protection agent that can combat hematopoietic damage caused by …
molecule radiation protection agent that can combat hematopoietic damage caused by …
Application of bismuth sulfide based nanomaterials in cancer diagnosis and treatment
Cancer is still the leading disease threatening human life and health at present. With the
development of nanotechnology, multifunctional nanomaterials integrated with different …
development of nanotechnology, multifunctional nanomaterials integrated with different …
Self-assembling polymer-based short chain fatty acid prodrugs ameliorate non-alcoholic steatohepatitis and liver fibrosis
B Shashni, Y Tajika, Y Ikeda, Y Nishikawa, Y Nagasaki - Biomaterials, 2023 - Elsevier
With the preponderance of a high-calorie diet and sedentary lifestyle, the prevalence of non-
alcoholic steatohepatitis (NASH), a state of abnormally elevated lipid accumulation in the …
alcoholic steatohepatitis (NASH), a state of abnormally elevated lipid accumulation in the …
Immunoregulatory Engineering of Semiconducting Charge‐Reversal Nanoantioxidant for Ameliorating Cancer Radioimmunotheranostics
W Ma, H Luo, J Lv, P Wen, G Liu, Z Yu… - Advanced …, 2024 - Wiley Online Library
Radiotherapy (RT) is a crucial clinical modality for cancer. However, nonselectivity, toxicity to
normal tissues, and radio‐resistance severely limit RT applications. This study develops a …
normal tissues, and radio‐resistance severely limit RT applications. This study develops a …
Self-assembling butyric acid prodrug acts as a sensitizer for cancer radiotherapy
B Shashni, Y Nagasaki - Nano Today, 2024 - Elsevier
Butyric acid, is reported to radiosensitize cancer cell lines in vitro. Their short systemic half-
lives may explain their lack of in vivo efficacy. To manage the unsuitable pharmacokinetics …
lives may explain their lack of in vivo efficacy. To manage the unsuitable pharmacokinetics …
Short-chain fatty acid-releasing nano-prodrugs for attenuating growth and metastasis of melanoma
B Shashni, Y Nagasaki - Acta biomaterialia, 2023 - Elsevier
Abstract Low-molecular-weight (LMW) short-chain fatty acids (SCFAs), such as propionic
and butyric acids, have been reported to possess anti-neoplastic effects; however, rapid …
and butyric acids, have been reported to possess anti-neoplastic effects; however, rapid …
Enhancement of proton therapy efficiency by noble metal nanoparticles is driven by the number and chemical activity of surface atoms
S Zwiehoff, J Johny, C Behrends, A Landmann… - Small, 2022 - Wiley Online Library
Proton‐based radiotherapy is a modern technique for the treatment of solid tumors with
significantly reduced side effects to adjacent tissues. Biocompatible nanoparticles (NPs) with …
significantly reduced side effects to adjacent tissues. Biocompatible nanoparticles (NPs) with …
The cellular and organismal effects of nitroxides and nitroxide-containing nanoparticles
I Sadowska-Bartosz, G Bartosz - International Journal of Molecular …, 2024 - mdpi.com
Nitroxides are stable free radicals that have antioxidant properties. They react with many
types of radicals, including alkyl and peroxyl radicals. They act as mimics of superoxide …
types of radicals, including alkyl and peroxyl radicals. They act as mimics of superoxide …
The anti-cancer effect of resveratrol nano-encapsulated supplements against breast cancer via the regulation of oxidative stress
Aim Several shreds of evidence have supported the growth-inhibitory effect of resveratrol in
breast cancer. Owing to the low efficiency, we aimed to fabricate an ACN nanoparticle …
breast cancer. Owing to the low efficiency, we aimed to fabricate an ACN nanoparticle …