Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Y Pan, W Tang, W Fan, J Zhang, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

Advances of amifostine in radiation protection: Administration and delivery

L Ji, P Cui, S Zhou, L Qiu, H Huang… - Molecular …, 2023 - ACS Publications
Amifostine (AMF, also known as WR-2721) is the only approved broad-spectrum small-
molecule radiation protection agent that can combat hematopoietic damage caused by …

Application of bismuth sulfide based nanomaterials in cancer diagnosis and treatment

Z Yang, L Wang, J Zhang, J Liu, X Yu - Nano Today, 2023 - Elsevier
Cancer is still the leading disease threatening human life and health at present. With the
development of nanotechnology, multifunctional nanomaterials integrated with different …

Self-assembling polymer-based short chain fatty acid prodrugs ameliorate non-alcoholic steatohepatitis and liver fibrosis

B Shashni, Y Tajika, Y Ikeda, Y Nishikawa, Y Nagasaki - Biomaterials, 2023 - Elsevier
With the preponderance of a high-calorie diet and sedentary lifestyle, the prevalence of non-
alcoholic steatohepatitis (NASH), a state of abnormally elevated lipid accumulation in the …

Immunoregulatory Engineering of Semiconducting Charge‐Reversal Nanoantioxidant for Ameliorating Cancer Radioimmunotheranostics

W Ma, H Luo, J Lv, P Wen, G Liu, Z Yu… - Advanced …, 2024 - Wiley Online Library
Radiotherapy (RT) is a crucial clinical modality for cancer. However, nonselectivity, toxicity to
normal tissues, and radio‐resistance severely limit RT applications. This study develops a …

Self-assembling butyric acid prodrug acts as a sensitizer for cancer radiotherapy

B Shashni, Y Nagasaki - Nano Today, 2024 - Elsevier
Butyric acid, is reported to radiosensitize cancer cell lines in vitro. Their short systemic half-
lives may explain their lack of in vivo efficacy. To manage the unsuitable pharmacokinetics …

Short-chain fatty acid-releasing nano-prodrugs for attenuating growth and metastasis of melanoma

B Shashni, Y Nagasaki - Acta biomaterialia, 2023 - Elsevier
Abstract Low-molecular-weight (LMW) short-chain fatty acids (SCFAs), such as propionic
and butyric acids, have been reported to possess anti-neoplastic effects; however, rapid …

Enhancement of proton therapy efficiency by noble metal nanoparticles is driven by the number and chemical activity of surface atoms

S Zwiehoff, J Johny, C Behrends, A Landmann… - Small, 2022 - Wiley Online Library
Proton‐based radiotherapy is a modern technique for the treatment of solid tumors with
significantly reduced side effects to adjacent tissues. Biocompatible nanoparticles (NPs) with …

The cellular and organismal effects of nitroxides and nitroxide-containing nanoparticles

I Sadowska-Bartosz, G Bartosz - International Journal of Molecular …, 2024 - mdpi.com
Nitroxides are stable free radicals that have antioxidant properties. They react with many
types of radicals, including alkyl and peroxyl radicals. They act as mimics of superoxide …

The anti-cancer effect of resveratrol nano-encapsulated supplements against breast cancer via the regulation of oxidative stress

S Sajadimajd, F Aghaz, M Khazaei… - Journal of …, 2023 - Taylor & Francis
Aim Several shreds of evidence have supported the growth-inhibitory effect of resveratrol in
breast cancer. Owing to the low efficiency, we aimed to fabricate an ACN nanoparticle …