Pharmacokinetic studies of a three-component complex that repurposes the front line antibiotic isoniazid against Mycobacterium tuberculosis
TJ Manning, K Wilkerson, T Holder, AC Bartley… - Tuberculosis, 2017 - Elsevier
The frontline tuberculosis (Tb) antibiotic isoniazid has been repurposed using a three
component complex aimed at increasing the delivery efficiency and adding new avenues to …
component complex aimed at increasing the delivery efficiency and adding new avenues to …
Structural and some medicinal characteristics of the copper (II)–hydroxychloroquine complex
TJ Manning, T Leggett, D Jenkins, I Furtado… - Bioorganic & medicinal …, 2013 - Elsevier
In the first phase of this study, the binding of hydroxychloroquine to the copper (II) cation is
examined using liquid chromatography–mass spectrometry (LC–MS), matrix assisted laser …
examined using liquid chromatography–mass spectrometry (LC–MS), matrix assisted laser …
Structural measurements and cell line studies of the copper–PEG–Rifampicin complex against Mycobacterium tuberculosis
T Manning, R Mikula, G Wylie, D Phillips… - Bioorganic & Medicinal …, 2015 - Elsevier
The bacterium responsible for tuberculosis is increasing its resistance to antibiotics resulting
in new multidrug-resistant Mycobacterium tuberculosis (MDR-TB) and extensively drug …
in new multidrug-resistant Mycobacterium tuberculosis (MDR-TB) and extensively drug …
Cell line studies and analytical measurements of three paclitaxel complex variations
The copper (II) cation, sucrose, and hydroxychloroquine were complexed with the
chemotherapy agent paclitaxel and studied for medicinal activity. Data (GI 50, LD 50) from …
chemotherapy agent paclitaxel and studied for medicinal activity. Data (GI 50, LD 50) from …