The extracellular matrix (ECM) is a highly complex structure through which biochemical and
mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a …

How periodic patterns are generated is an open question. A number of mechanisms have
been proposed–most famously, Turing's reaction-diffusion model. However, many …

Explaining embryonic development of multicellular organisms requires insight into complex
interactions between genetic regulation and physical, generic mechanisms at multiple …

Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and
intestinal villi, during development. The Turing reaction–diffusion system posits that …

In this paper we present the foundation of a unified, object-oriented, three-dimensional
biomodelling environment, which allows us to integrate multiple submodels at scales from …

This chapter discusses the history and development of what we propose to rename the
Glazier-Graner-Hogeweg model (GGH model), starting with its ancestors, simple models of …

Many biological patterns, from population densities to animal coat markings, can be thought
of as heterogeneous spatiotemporal distributions of mobile agents. Many mathematical …

Cell-based, mathematical models help make sense of morphogenesis—ie cells organizing
into shape and pattern—by capturing cell behavior in simple, purely descriptive models. Cell …

The actions of cell adhesion molecules, in particular, cadherins during embryonic
development and morphogenesis more generally, regulate many aspects of cellular …

A central question in developmental biology is how cells interact to organize into tissues? In
this paper, we study the role of mesenchyme-ectoderm interaction in the growing chick limb …