Advances in genomics and innovative strategies such as reverse vaccinology have changed
the concepts and approaches to vaccine candidate selection and design. Genome mining …

Vaccination has played a significant role in controlling and eliminating life-threatening
infectious diseases throughout the world, and yet currently licensed vaccines represent only …

The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among
HIV-infected individuals. We utilized the completed genome sequence and optimized …

Salmonella enterica serovar Typhimurium must successfully transition the broad fluctuations
in oxygen concentrations encountered in the host. In Escherichia coli, FNR is one of the …

During infection Neisseria meningitidis (Nm) encounters multiple environments within the
host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the …

Fungal pathogens of humans require molecular oxygen for several essential biochemical
reactions, yet virtually nothing is known about how they adapt to the relatively hypoxic …

Molecular oxygen (O2) and nitric oxide (NO) are diatomic gases that play major roles in
infection. The host innate immune system generates reactive oxygen species and NO as …

A longstanding question in infection biology addresses the genetic basis for invasive
behavior in commensal pathogens. A prime example for such a pathogen is Neisseria …

Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo
survival and virulence of bacterial pathogens. The first OMV vaccines successfully stopped …

Abstract Background The Ferric uptake regulator (Fur) is a transcriptional regulator that
controls iron homeostasis in bacteria. Although the regulatory role of Fur in Escherichia coli …