The changing therapeutic landscape of head and neck cancer

JD Cramer, B Burtness, QT Le, RL Ferris - Nature reviews Clinical …, 2019 - nature.com
Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …

Oral cavity and oropharyngeal squamous cell carcinoma—an update

AC Chi, TA Day, BW Neville - CA: a cancer journal for clinicians, 2015 - Wiley Online Library
Answer questions and earn CME/CNE Oral cavity squamous cell carcinoma (OC‐SCC) is
the most common malignancy of the head and neck (excluding nonmelanoma skin cancer) …

NCCN Guidelines® insights: Head and neck cancers, version 1.2022: Featured updates to the NCCN guidelines

JJ Caudell, ML Gillison, E Maghami, S Spencer… - Journal of the National …, 2022 - jnccn.org
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity
(including mucosal lip), pharynx, larynx, and paranasal sinuses. Occult primary cancer …

Human papillomavirus testing in head and neck carcinomas: guideline from the College of American Pathologists

JS Lewis Jr, B Beadle, JA Bishop… - … of pathology & …, 2018 - meridian.allenpress.com
Context Human papillomavirus (HPV) is a major cause of oropharyngeal squamous cell
carcinomas, and HPV (and/or surrogate marker p16) status has emerged as a prognostic …

Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for …

B O'Sullivan, SH Huang, J Su, AS Garden… - The Lancet …, 2016 - thelancet.com
Background Human papillomavirus-related (HPV+) oropharyngeal cancer is a rapidly
emerging disease with generally good prognosis. Many prognostic algorithms for …

[HTML][HTML] Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 …

RL Ferris, WC Spanos, R Leidner… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Head and neck squamous cell carcinomas (HNSCCs) are common
malignancies caused by carcinogens, including tobacco and alcohol, or infection with …

Epidemiology of head and neck cancer

EM Rettig, G D'Souza - Surgical oncology clinics, 2015 - surgonc.theclinics.com
Head and neck cancer (HNC) encompasses a heterogeneous group of upper aerodigestive
tract malignancies that together comprise the seventh most common cancer worldwide, 1 …

Consensuses, controversies, and future directions in treatment deintensification for human papillomavirus‐associated oropharyngeal cancer

JJ Kang, Y Yu, L Chen, K Zakeri… - CA: a cancer journal …, 2023 - Wiley Online Library
The most common cancer caused by human papillomavirus (HPV) infection in the United
States is oropharyngeal cancer (OPC), and its incidence has been rising since the turn of the …

NCCN guidelines insights: head and neck cancers, version 2.2017

D Adelstein, ML Gillison, DG Pfister, S Spencer… - Journal of the National …, 2017 - jnccn.org
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck
Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx …

[HTML][HTML] Implications of genetic and epigenetic alterations of CDKN2A (p16INK4a) in cancer

R Zhao, BY Choi, MH Lee, AM Bode, Z Dong - EBioMedicine, 2016 - thelancet.com
Aberrant gene silencing is highly associated with altered cell cycle regulation during
carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which …