Next-generation sequencing has transformed our knowledge of the genetics of lymphoid
malignancies. However, limited experimental systems are available to model the functional …

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. Over
the previous 2 decades, tremendous progress has been made in our understanding of the …

Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system,
in which the water-channel protein AQP4 is the target antigen. The immunopathology in …

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified
in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis …

Biomolecular condensates are membraneless compartments that impart spatial and
temporal organization to cells. Condensates can undergo maturation, transitioning from …

Multicellular life requires altruistic cooperation between cells. The adaptive immune system
is a notable exception, wherein germinal center B cells compete vigorously for limiting …

DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA
biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for …

Aberrant B-cell receptor/NF-κB signaling is a hallmark feature of B-cell non-Hodgkin
lymphomas, especially in diffuse large B-cell lymphoma (DLBCL). Recurrent mutations in …

Introduction Epstein-Barr virus (EBV) infection in humans is associated with a wide range of
diseases including malignancies of different origins, most prominently B cells. Several EBV …

Follicular lymphoma (FL) is morphologically and clinically diverse, with mutations in
epigenetic regulators alongside t (14; 18) identified as disease-initiating events …