Pathophysiology of placental-derived fetal growth restriction

GJ Burton, E Jauniaux - American journal of obstetrics and gynecology, 2018 - Elsevier
Placental-related fetal growth restriction arises primarily due to deficient remodeling of the
uterine spiral arteries supplying the placenta during early pregnancy. The resultant …

The pivotal role of the placenta in normal and pathological pregnancies: a focus on preeclampsia, fetal growth restriction, and maternal chronic venous disease

MA Ortega, O Fraile-Martínez, C García-Montero… - Cells, 2022 - mdpi.com
The placenta is a central structure in pregnancy and has pleiotropic functions. This organ
grows incredibly rapidly during this period, acting as a mastermind behind different fetal and …

Improving pregnancy outcomes in humans through studies in sheep

JL Morrison, MJ Berry, KJ Botting… - American Journal …, 2018 - journals.physiology.org
Experimental studies that are relevant to human pregnancy rely on the selection of
appropriate animal models as an important element in experimental design. Consideration …

Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

AN Sferruzzi‐Perri, I Sandovici… - The Journal of …, 2017 - Wiley Online Library
The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …

Mechanisms of adiponectin action in fertility: an overview from gametogenesis to gestation in humans and animal models in normal and pathological conditions

A Barbe, A Bongrani, N Mellouk, A Estienne… - International journal of …, 2019 - mdpi.com
Adiponectin is the most abundant plasma adipokine. It mainly derives from white adipose
tissue and plays a key role in the control of energy metabolism thanks to its insulin …

Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta

BV Natale, KN Gustin, K Lee, AC Holloway… - Scientific reports, 2020 - nature.com
Abstract 1 in 5 women report cannabis use during pregnancy, with nausea cited as their
primary motivation. Studies show that (-)-△ 9–tetrahydrocannabinol (Δ9-THC), the major …

The placenta: a maternofetal interface

K O'Brien, Y Wang - Annual Review of Nutrition, 2023 - annualreviews.org
The placenta is the gatekeeper between the mother and the fetus. Over the first trimester of
pregnancy, the fetus is nourished by uterine gland secretions in a process known as …

Trophoblast-specific expression of Hif-1α results in preeclampsia-like symptoms and fetal growth restriction

RE Albers, MR Kaufman, BV Natale, C Keoni… - Scientific Reports, 2019 - nature.com
The placenta is an essential organ that is formed during pregnancy and its proper
development is critical for embryonic survival. While several animal models have been …

Human chorionic villous differentiation and placental development

J Kojima, M Ono, N Kuji, H Nishi - International Journal of Molecular …, 2022 - mdpi.com
In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

Knowledge gaps and emerging research areas in intrauterine growth restriction-associated brain injury

B Fleiss, F Wong, F Brownfoot, IK Shearer… - Frontiers in …, 2019 - frontiersin.org
Intrauterine growth restriction (IUGR) is a complex global healthcare issue. Concerted
research and clinical efforts have improved our knowledge of the neurodevelopmental …