Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities
B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …
endogenous characteristics, however, further bioengineering refinement is required to …
Extracellular vesicles in cardiovascular disease: biological functions and therapeutic implications
Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer
particles naturally released from the cell. While exosomes are formed as intraluminal …
particles naturally released from the cell. While exosomes are formed as intraluminal …
Microneedle patch loaded with exosomes containing microRNA‐29b prevents cardiac fibrosis after myocardial infarction
J Yuan, H Yang, C Liu, L Shao, H Zhang… - Advanced …, 2023 - Wiley Online Library
Myocardial infarction (MI) is a cardiovascular disease that poses a serious threat to human
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …
Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis …
Current treatments including drug therapy, medical device implantation, and organ
transplantation have considerable shortcomings for myocardial infarction (MI), such as high …
transplantation have considerable shortcomings for myocardial infarction (MI), such as high …
Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine
D Lopes, J Lopes, M Pereira-Silva, D Peixoto… - Military Medical …, 2023 - Springer
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with
biomembranes, such as natural cell membranes or subcellular structure-derived …
biomembranes, such as natural cell membranes or subcellular structure-derived …
Extracellular vesicles as next generation immunotherapeutics
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …
[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …
[HTML][HTML] MOF-derived bimetallic nanozyme to catalyze ROS scavenging for protection of myocardial injury
K Xiang, H Wu, Y Liu, S Wang, X Li, B Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Myocardial injury triggers intense oxidative stress, inflammatory response, and
cytokine release, which are essential for myocardial repair and remodeling. Excess reactive …
cytokine release, which are essential for myocardial repair and remodeling. Excess reactive …
Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction
Y Wang, J Wang, C Liu, J Li, K Lu, Q Yu… - Journal of Materials …, 2023 - Elsevier
Excessive cardiac fibrosis impairs cardiac repair after myocardial infarction (MI). In this work,
an injectable composite hydrogel integrating natural biomaterials, exosomes, and bioactive …
an injectable composite hydrogel integrating natural biomaterials, exosomes, and bioactive …
M2 Macrophage‐Derived sEV Regulate Pro‐Inflammatory CCR2+ Macrophage Subpopulations to Favor Post‐AMI Cardiac Repair
L Li, J Cao, S Li, T Cui, J Ni, H Zhang, Y Zhu… - Advanced …, 2023 - Wiley Online Library
Tissue‐resident cardiac macrophage subsets mediate cardiac tissue inflammation and
repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing …
repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing …