Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …

Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and
the number of CRC patients is increasing progressively. Despite the improvement of the …

Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways
that play key roles for tissue maintenance. In particular, it is important in the context of …

Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …

The emergence of disseminated metastases remains the primary cause of mortality in
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Transforming growth factor β (TGF-β) signaling pathway plays important roles in many
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …

Myeloid-derived suppressor cells (MDSCs) expand in tumor-bearing host. They suppress
anti-tumor immune response and promote tumor growth. Chemokines play a vital role in …