Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations
The tricarboxylic acid, or Krebs, cycle is central to the cellular metabolism of sugars, lipids,
and amino acids; it fuels the mitochondrial respiratory chain for energy generation. In the …
and amino acids; it fuels the mitochondrial respiratory chain for energy generation. In the …
Molecular subtypes of KIT/PDGFRA wild-type gastrointestinal stromal tumors: a report from the National Institutes of Health Gastrointestinal Stromal Tumor Clinic
SA Boikos, AS Pappo, JK Killian, MP LaQuaglia… - JAMA …, 2016 - jamanetwork.com
Importance Wild-type (WT) gastrointestinal stromal tumors (GISTs), which
lackKITandPDGFRAgene mutations, are the primary form of GIST in children and …
lackKITandPDGFRAgene mutations, are the primary form of GIST in children and …
Heterogeneity of tumor-induced gene expression changes in the human metabolic network
Reprogramming of cellular metabolism is an emerging hallmark of neoplastic
transformation. However, it is not known how the expression of metabolic genes in tumors …
transformation. However, it is not known how the expression of metabolic genes in tumors …
Isocitrate dehydrogenase mutations in leukemia
AS McKenney, RL Levine - The Journal of Clinical …, 2013 - Am Soc Clin Investig
Recent genome-wide discovery studies have identified a spectrum of mutations in different
malignancies and have led to the elucidation of novel pathways that contribute to oncogenic …
malignancies and have led to the elucidation of novel pathways that contribute to oncogenic …
Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production
Mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2
can lead to R (−)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site …
can lead to R (−)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site …
Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid …
S Chotirat, W Thongnoppakhun… - Journal of hematology & …, 2012 - Springer
Background Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode
cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α …
cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α …
IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors
M Mellai, A Piazzi, V Caldera, O Monzeglio… - Journal of neuro …, 2011 - Springer
A total of 343 brain tumors were studied for IDH1 and IDH2 mutations by direct sequencing
and for protein expression by immunohistochemistry with mIDH1 R132H antibody. Of these …
and for protein expression by immunohistochemistry with mIDH1 R132H antibody. Of these …
IDH1 and IDH2 mutations in pediatric acute leukemia
AK Andersson, DW Miller, JA Lynch, AS Lemoff, Z Cai… - Leukemia, 2011 - nature.com
To investigate the frequency of isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) mutations in
pediatric acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), we sequenced …
pediatric acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), we sequenced …
IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
J Lin, D Yao, J Qian, Q Chen, W Qian, Y Li, J Yang… - Annals of …, 2012 - Springer
The somatic mutations of isocitrate dehydrogenase genes (IDH1 and IDH2) have been
identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 …
identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 …
[HTML][HTML] Methylation alterations and advance of treatment in lymphoma
MK Liu, XJ Sun, XD Gao, Y Qian, L Wang… - Frontiers in Bioscience …, 2021 - imrpress.com
Lymphoma is a common and aggressive form of hematopoietic malignancies with diverse
clinical and pathological features due to its heterogeneity. Although the current …
clinical and pathological features due to its heterogeneity. Although the current …