Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls
Sequential reactions of aminoalkynes represent a powerful tool to easily assembly
biologically important polyfunctionalized nitrogen heterocyclic scaffolds. Metal catalysis …
biologically important polyfunctionalized nitrogen heterocyclic scaffolds. Metal catalysis …
Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR
EM Eliwa, M Frese, AH Halawa, MM Soltan… - … chemistry letters and …, 2021 - Taylor & Francis
ABSTRACT A metal-free, atom-economy and simple work-up domino amination-
Knoevenagel condensation approach to construct new coumarin analogous (4a-f and 8a-e) …
Knoevenagel condensation approach to construct new coumarin analogous (4a-f and 8a-e) …
Synthesis of diverse pentasubstituted pyrroles by a gold (I)-catalyzed cascade rearrangement-cyclization of tertiary enamide
W Li, R Shi, S Chen, X Zhang, W Peng… - The Journal of …, 2022 - ACS Publications
An efficient Au (I)-catalyzed intramolecular cascade reaction of tertiary enamides tethered an
alkynyl group has been developed. The process is composed of a propargyl-claisen …
alkynyl group has been developed. The process is composed of a propargyl-claisen …
Synthesis and Application of Novel Magnetic Glycoluril Tetrakis(Methylene Phosphorous Acid) as a Nano Biological Catalyst for the Preparation of Nicotinonitriles via …
B Danishyar, H Sepehrmansourie, M Zarei… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Herein, we synthesized biological magnetic glycoluril tetrakis (methylene phosphorous acid)
as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe3O4@ GTMPA was …
as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe3O4@ GTMPA was …
Cu-catalyzed pyridine synthesis via oxidative annulation of cyclic ketones with propargylamine
SO Sotnik, AI Subota, AY Kliuchynskyi… - The Journal of …, 2021 - ACS Publications
A Cu-catalyzed, easily scalable one-pot synthesis of fused pyridines by the reaction of cyclic
ketones with propargylamine is described. The protocol was optimized based on the results …
ketones with propargylamine is described. The protocol was optimized based on the results …
IBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines
P Gao, HJ Chen, ZJ Bai, MN Zhao, D Yang… - The Journal of …, 2020 - ACS Publications
An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines
was developed. Through this strategy, a variety of 2, 3-disubstituted pyrroles and pyridines …
was developed. Through this strategy, a variety of 2, 3-disubstituted pyrroles and pyridines …
N-propargyl aza-Claisen rearrangement in the synthesis of heterocycles
Pericyclic reactions present a convenient tool for constructing heterocyclic systems. They
make possible to obtain quite complex structures in one step with high yields and …
make possible to obtain quite complex structures in one step with high yields and …
Recent advances in synthesis and reactions of β-amino-α, β-enones (Enaminones)
T Farghaly, AM Abo Alnaja… - Current Organic …, 2021 - ingentaconnect.com
β-Amino-α, β-enones or β-enamino carbonyl compounds are versatile synthons
intermediates for the construction of various bio-active heterocyclic compounds and have …
intermediates for the construction of various bio-active heterocyclic compounds and have …
Synthesis of multi-arylated pyridines via tandem oxidative reaction
D Cheng, H Yang, C Yu, Y Tao, X Xu - Tetrahedron Letters, 2022 - Elsevier
An efficient tandem reaction of β-enaminoesters and 1, 3-diarylpropenes is disclosed. It
undergoes oxidative coupling mediated by DDQ, subsequent intermolecular cyclization and …
undergoes oxidative coupling mediated by DDQ, subsequent intermolecular cyclization and …
One-Pot Synthetic Approach to 3-Carboxyl-and 3-Ketopyridines in Aqueous Media
AR Bena, EG Bakalbassis, MM Sigalas… - The Journal of Organic …, 2023 - ACS Publications
We describe a one-pot strategy to access 3-carboxyl-and 3-ketopyridines from readily
available alkynes and propargylamine via a hydroamination process. This one-pot protocol …
available alkynes and propargylamine via a hydroamination process. This one-pot protocol …