Synthesis of Nitrogen-Containing Heterocyclic Scaffolds through Sequential Reactions of Aminoalkynes with Carbonyls

A Arcadi, V Morlacci, L Palombi - Molecules, 2023 - mdpi.com
Sequential reactions of aminoalkynes represent a powerful tool to easily assembly
biologically important polyfunctionalized nitrogen heterocyclic scaffolds. Metal catalysis …

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

EM Eliwa, M Frese, AH Halawa, MM Soltan… - … chemistry letters and …, 2021 - Taylor & Francis
ABSTRACT A metal-free, atom-economy and simple work-up domino amination-
Knoevenagel condensation approach to construct new coumarin analogous (4a-f and 8a-e) …

Synthesis of diverse pentasubstituted pyrroles by a gold (I)-catalyzed cascade rearrangement-cyclization of tertiary enamide

W Li, R Shi, S Chen, X Zhang, W Peng… - The Journal of …, 2022 - ACS Publications
An efficient Au (I)-catalyzed intramolecular cascade reaction of tertiary enamides tethered an
alkynyl group has been developed. The process is composed of a propargyl-claisen …

Synthesis and Application of Novel Magnetic Glycoluril Tetrakis(Methylene Phosphorous Acid) as a Nano Biological Catalyst for the Preparation of Nicotinonitriles via …

B Danishyar, H Sepehrmansourie, M Zarei… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Herein, we synthesized biological magnetic glycoluril tetrakis (methylene phosphorous acid)
as a new heterogeneous nano-catalyst. The magnetic nano-catalyst Fe3O4@ GTMPA was …

Cu-catalyzed pyridine synthesis via oxidative annulation of cyclic ketones with propargylamine

SO Sotnik, AI Subota, AY Kliuchynskyi… - The Journal of …, 2021 - ACS Publications
A Cu-catalyzed, easily scalable one-pot synthesis of fused pyridines by the reaction of cyclic
ketones with propargylamine is described. The protocol was optimized based on the results …

IBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines

P Gao, HJ Chen, ZJ Bai, MN Zhao, D Yang… - The Journal of …, 2020 - ACS Publications
An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines
was developed. Through this strategy, a variety of 2, 3-disubstituted pyrroles and pyridines …

N-propargyl aza-Claisen rearrangement in the synthesis of heterocycles

AV Listratova, AA Titov, AY Obydennik, AV Varlamov - Tetrahedron, 2022 - Elsevier
Pericyclic reactions present a convenient tool for constructing heterocyclic systems. They
make possible to obtain quite complex structures in one step with high yields and …

Recent advances in synthesis and reactions of β-amino-α, β-enones (Enaminones)

T Farghaly, AM Abo Alnaja… - Current Organic …, 2021 - ingentaconnect.com
β-Amino-α, β-enones or β-enamino carbonyl compounds are versatile synthons
intermediates for the construction of various bio-active heterocyclic compounds and have …

Synthesis of multi-arylated pyridines via tandem oxidative reaction

D Cheng, H Yang, C Yu, Y Tao, X Xu - Tetrahedron Letters, 2022 - Elsevier
An efficient tandem reaction of β-enaminoesters and 1, 3-diarylpropenes is disclosed. It
undergoes oxidative coupling mediated by DDQ, subsequent intermolecular cyclization and …

One-Pot Synthetic Approach to 3-Carboxyl-and 3-Ketopyridines in Aqueous Media

AR Bena, EG Bakalbassis, MM Sigalas… - The Journal of Organic …, 2023 - ACS Publications
We describe a one-pot strategy to access 3-carboxyl-and 3-ketopyridines from readily
available alkynes and propargylamine via a hydroamination process. This one-pot protocol …