Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and
immunological entities caused by dysregulation in the innate immune system. Since then …

Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have
important roles in metabolic homeostasis. The molecular identification of genes encoding …

Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder of
children and young adults that is characterized by nonbacterial osteomyelitis. Patients …

Abstract Infevers (Internet Fevers; http://fmf. igh. cnrs. fr/ISSAID/infevers), a website
dedicated to mutations responsible for hereditary autoinflammatory diseases, was created in …

Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory disorder that primarily
affects children. Its hallmark is recurring episodes of sterile osteomyelitis. The clinical …

Background and objective Majeed syndrome is an autosomal recessive disorder
characterised by the triad of chronic recurrent multifocal osteomyelitis, congenital …

Mutations in human LPIN2 produce a disease known as Majeed syndrome, the clinical
manifestations of which are ameliorated by strategies that block IL-1β or its receptor …

The regulation of glycerolipid biosynthesis is critical for homeostasis of cellular lipid stores
and membranes. Here we review the role of lipin phosphatidic acid phosphatase enzymes …

Lipin family proteins are emerging as crucial regulators of lipid metabolism. In triglyceride
synthesis, lipins act as lipid phosphatase enzymes at the endoplasmic reticular membrane …