After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …

HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …

Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of
infected individuals (here termed 'elite controllers'), despite the presence of a replication …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

HIV-1 capsid core disassembly (uncoating) must occur before integration of viral genomic
DNA into the host chromosomes, yet remarkably, the timing and cellular location of …

The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-
acting antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and thereby …

Retroviral infection involves the reverse transcription of the viral RNA genome into DNA,
which is subsequently integrated into the host cell genome. Human immunodeficiency virus …

We recently reported that HIV-1 cores that retained> 94% of their capsid (CA) protein
entered the nucleus and disassembled (uncoated) near their integration site< 1.5 h before …

HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that
this entry proceeds through nuclear pore complexes (NPCs), with the 120× 60 nm capsid …