Ion channels are transmembrane proteins ubiquitously expressed in all cells that control
various ions (eg Na+, K+, Ca 2+ and Cl-etc) crossing cellular plasma membrane, which play …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

In males but not in females, brain derived neurotrophic factor (BDNF) plays an obligatory
role in the onset and maintenance of neuropathic pain. Afferent terminals of injured …

Osteoarthritis (OA) is a currently incurable, chronic, progressive, and debilitating
musculoskeletal (MSK) condition. One of its hallmark symptoms is chronic nociceptive and …

Patients with neuropathic pain are heterogeneous in pathophysiology, etiology, and clinical
presentation. Signs and symptoms are determined by the nature of the injury and factors …

Abstract Thrombospondin-4 (TSP-4) belongs to the extracellular matrix glycoprotein family of
thrombospondins (TSPs). The multidomain, pentameric structure of TSP-4 allows its …

We show here that hyperpolarization‐activated current (Ih) unexpectedly acts to inhibit the
activity of dorsal root ganglion (DRG) neurons expressing WT Nav1. 7, the largest inward …

The aim of this study was to assess the patterns and trends of pharmacological treatment for
outpatients with postherpetic neuralgia (PHN) in China in the period 2015–2019 …

The goals of this review are to improve understanding of the aetiology of chronic muscle
pain and identify new targets for treatments. Muscle pain is usually associated with trigger …

Nociceptive sensory neurons convey pain-related signals to the CNS using action
potentials. Loss-of-function mutations in the voltage-gated sodium channel Na V 1.7 cause …