The role of inflammation in the pathogenesis of preeclampsia

M Michalczyk, A Celewicz, M Celewicz… - Mediators of …, 2020 - Wiley Online Library
Preeclampsia (PE) affects 5‐8% of pregnant women, and it is the major cause of perinatal
morbidity and mortality. It is defined as arterial hypertension in women after 20 weeks of …

[HTML][HTML] The human HSP70 family of chaperones: where do we stand?

J Radons - Cell Stress and Chaperones, 2016 - Elsevier
The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface

A Lu-Culligan, AR Chavan, P Vijayakumar, L Irshaid… - Med, 2021 - cell.com
Background Pregnant women are at increased risk for severe outcomes from coronavirus
disease 2019 (COVID-19), but the pathophysiology underlying this increased morbidity and …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

HELLP syndrome—holistic insight into pathophysiology

A Petca, BC Miron, I Pacu, MC Dumitrașcu… - Medicina, 2022 - mdpi.com
HELLP syndrome, also known as the syndrome of hemolysis, elevated liver enzymes, and
low platelets, represents a severe pregnancy complication typically associated with …

Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array

A Szarka, J Rigó, L Lázár, G Bekő, A Molvarec - BMC immunology, 2010 - Springer
Background Preeclampsia is a severe complication of pregnancy characterized by an
excessive maternal systemic inflammatory response with activation of both the innate and …

Red cell DAMPs and inflammation

R Mendonça, AAA Silveira, N Conran - Inflammation Research, 2016 - Springer
Intravascular hemolysis, or the destruction of red blood cells in the circulation, can occur in
numerous diseases, including the acquired hemolytic anemias, sickle cell disease and β …

Extracellular heat shock proteins: a new location, a new function

A De Maio, D Vazquez - Shock, 2013 - journals.lww.com
The expression of heat shock proteins (HSPs) is a basic and well-conserved cellular
response to an array of stresses. These proteins are involved in the repair of cellular …

Placental derived biomarkers of pregnancy disorders

JSM Cuffe, O Holland, C Salomon, GE Rice… - Placenta, 2017 - Elsevier
Pregnancy is one of the greatest physiological challenges that a women can experience.
The physiological adaptations that accompany pregnancy may increase the risk of …

Novel roles of peroxiredoxins in inflammation, cancer and innate immunity

T Ishii, E Warabi, T Yanagawa - Journal of clinical biochemistry and …, 2012 - jstage.jst.go.jp
抄録 Peroxiredoxins possess thioredoxin or glutathione peroxidase and chaperone-like
activities and thereby protect cells from oxidative insults. Recent studies, however, reveal …