Neuroblastoma is a tumour derived from primitive cells of the sympathetic nervous system
and is the most common solid tumour in childhood. Interestingly, most infants experience …

PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm
in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic …

Neuroblastoma (NB), the most common extracranial solid tumor in childhood, is an
extremely heterogeneous disease both biologically and clinically. Although significant …

Neuroblastoma is remarkable for its clinical heterogeneity and is characterized by genomic
alterations that are strongly correlated with tumor behavior. The specific genes that influence …

Purpose Amplification of the transcription factor MYCN is an important molecular diagnostic
tool in stratifying treatment for neuroblastoma. Increased copy number and overexpression …

The application of comparative genomic hybridization to the analysis of genetic
abnormalities in breast carcinoma has consistently revealed that chromosome region 17q22 …

Neuroblastoma is one of the most frequently occurring solid tumours in children, especially
in the first year of life, when it accounts for 50% of all tumours. It is the second most common …

Neuroblastoma is one of the most frequent, yet distinctive and challenging childhood tumors.
The uniqueness of this tumor depends on its biological markers, which classify …

More than 20 years ago, Schwab and colleagues [1] identified multiple copies of the MYC-
related oncogene, MYCN, in a panel of neuroblastoma cell lines and a neuroblastoma …

Cumulative information available about the organization of amplified chromosomal regions
in human tumors suggests that the amplification repeat units, or amplicons, can be of a …