Parkinson disease (PD) is the second most common neurodegenerative disorder, affecting>
1% of the population≥ 65 years of age and with a prevalence set to double by 2030. In …

For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

With the growing awareness of the presence of non-motor symptoms in Parkinson's disease
(PD) has come the realization that these non-motor features play a tremendously important …

Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in
the context of various neurological diseases. The high prevalence of fatigue as either a …

Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the
cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show …

Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Despite increasing evidence suggesting the cerebellum works in concert with the cortex and
basal ganglia, the nature of the reciprocal interactions between these three brain regions …

Abstract Purpose of Review The sense of smell is today one of the focuses of interest in
aging and neurodegenerative disease research. In several neurodegenerative diseases …

Objective To investigate whether diabetes mellitus is associated with Parkinson-like
pathology in people without Parkinson disease and to evaluate the effect of diabetes …