The eukaryotic heat shock response is an ancient and highly conserved transcriptional
program that results in the immediate synthesis of a battery of cytoprotective genes in the …

Mitochondria are compartmentalized organelles essential for numerous cellular functions
including ATP generation, iron-sulfur cluster biogenesis, nucleotide and amino acid …

As essential organelles, mitochondria are intimately integrated into the metabolism of a
eukaryotic cell. The maintenance of the functional integrity of the mitochondrial proteome …

Abstract Mortalin/mthsp70/PBP74/Grp75 (called mortalin hereafter), a member of the Hsp70
family of chaperones, was shown to have different subcellular localizations in normal and …

Classic Hsp70 chaperones assist in diverse processes of protein folding and translocation,
and Hsp110s had seemed by sequence to be distant relatives within an Hsp70 superfamily …

Hsp70s and J-proteins, which constitute one of the most ubiquitous types of molecular
chaperone machineries, function in a wide variety of cellular processes. J-proteins play a …

The molecular chaperone and cytoprotective activities of the Hsp70 and Hsp40 chaperones
represent therapeutic targets for human diseases such as cancer and those that arise from …

To maintain healthy mitochondrial enzyme content and function, mitochondria possess a
complex protein quality control system, which is composed of different endogenous sets of …

The major Hsp70 of the mitochondrial matrix (Ssc1 in yeast) is critically important for the
translocation of proteins from the cytosol, across the mitochondrial inner membrane, and into …

Proteins in a natural environment are constantly challenged by stress conditions, causing
their destabilization, unfolding, and, ultimately, aggregation. Protein aggregation has been …