The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain

ME Salliss, LV Farland, ND Mahnert… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Endometriosis is a chronic, burdensome condition that is historically
understudied. Consequently, there is a lack of understanding of the etiology of the disease …

The microbiome and gynaecological cancer development, prevention and therapy

P Łaniewski, ZE Ilhan, MM Herbst-Kralovetz - Nature Reviews Urology, 2020 - nature.com
The female reproductive tract (FRT), similar to other mucosal sites, harbours a site-specific
microbiome, which has an essential role in maintaining health and homeostasis. In the …

Uterine microbiota: residents, tourists, or invaders?

JM Baker, DM Chase, MM Herbst-Kralovetz - Frontiers in immunology, 2018 - frontiersin.org
Uterine microbiota have been reported under various conditions and populations; however,
it is uncertain the level to which these bacteria are residents that maintain homeostasis …

How uterine microbiota might be responsible for a receptive, fertile endometrium

M Benner, G Ferwerda, I Joosten… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Fertility depends on a receptive state of the endometrium, influenced by
hormonal and anatomical adaptations, as well as the immune system. Local and systemic …

Bacterial vaginosis and health-associated bacteria modulate the immunometabolic landscape in 3D model of human cervix

P Łaniewski, MM Herbst-Kralovetz - npj Biofilms and Microbiomes, 2021 - nature.com
Bacterial vaginosis (BV) is an enigmatic polymicrobial condition characterized by a
depletion of health-associated Lactobacillus and an overgrowth of anaerobes. Importantly …

Uterine immunity and microbiota: a shifting paradigm

C Agostinis, A Mangogna, F Bossi, G Ricci… - Frontiers in …, 2019 - frontiersin.org
The female reproductive tract harbors distinct microbial communities, as in the vagina,
cervical canal, uterus, and fallopian tubes. The nature of the vaginal microbiota is well …

Host–vaginal microbiota interactions in the pathogenesis of bacterial vaginosis

CA Muzny, P Łaniewski, JR Schwebke… - Current opinion in …, 2020 - journals.lww.com
Elucidating the cause of bacterial vaginosis has important implications for diagnosis and
treatment. Our current bacterial vaginosis pathogenesis model provides a framework for key …

Modeling host-pathogen interactions in the context of the microenvironment: three-dimensional cell culture comes of age

J Barrila, A Crabbé, J Yang, K Franco… - Infection and …, 2018 - Am Soc Microbiol
Tissues and organs provide the structural and biochemical landscapes upon which
microbial pathogens and commensals function to regulate health and disease. While flat two …

Organoid systems to study the human female reproductive tract and pregnancy

L Alzamil, K Nikolakopoulou, MY Turco - Cell Death & Differentiation, 2021 - nature.com
Both the proper functioning of the female reproductive tract (FRT) and normal placental
development are essential for women's health, wellbeing, and pregnancy outcome. The …

Bacterial colonization of the female upper genital tract

A Peric, J Weiss, N Vulliemoz, D Baud… - International journal of …, 2019 - mdpi.com
Bacteria colonize most of the human body, and the female genital tract is not an exception.
While the existence of a vaginal microbiota has been well established, the upper genital …