New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
[HTML][HTML] AMPK: restoring metabolic homeostasis over space and time
E Trefts, RJ Shaw - Molecular cell, 2021 - cell.com
The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …
cellular energetic homeostasis. Recent work has been critical in establishing the …
[HTML][HTML] AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
[HTML][HTML] Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study
S Xu, X Li, S Zhang, C Qi, Z Zhang, R Ma, L Xiang… - BMC medicine, 2023 - Springer
Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's
disease (CD). OS-related genes can be affected by environmental factors, intestinal …
disease (CD). OS-related genes can be affected by environmental factors, intestinal …
[HTML][HTML] AMP-activated protein kinase: the current landscape for drug development
GR Steinberg, D Carling - Nature reviews Drug discovery, 2019 - nature.com
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …
homeostasis, many exciting insights into its structure, regulation and physiological roles …
AMPK and autophagy
Y Li, Y Chen - Autophagy: Biology and Diseases: Basic Science, 2019 - Springer
AMPK is an evolutionarily conserved serine/threonine-protein kinase that acts as an energy
sensor in cells and plays a key role in the upregulation of catabolism and inactivation of …
sensor in cells and plays a key role in the upregulation of catabolism and inactivation of …
AMPK: guardian of metabolism and mitochondrial homeostasis
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
[HTML][HTML] AMPK: sensing glucose as well as cellular energy status
Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …
[HTML][HTML] AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance
D Garcia, RJ Shaw - Molecular cell, 2017 - cell.com
AMPK is a highly conserved master regulator of metabolism, which restores energy balance
during metabolic stress both at the cellular and physiological levels. The identification of …
during metabolic stress both at the cellular and physiological levels. The identification of …
Fructose-1, 6-bisphosphate and aldolase mediate glucose sensing by AMPK
The major energy source for most cells is glucose, from which ATP is generated via
glycolysis and/or oxidative metabolism. Glucose deprivation activates AMP-activated protein …
glycolysis and/or oxidative metabolism. Glucose deprivation activates AMP-activated protein …