Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …

The inflammatory disorders collectively termed the seronegative spondyloarthropathies
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …

During the last decades, high-throughput assessment of gene expression in patient tissues
using microarray technology or RNA-Seq took center stage in clinical research. Insights into …

Psoriasis is a chronic inflammatory condition characterized by systemic immune
dysregulation. Over the past several years, advances in genetics, microbiology …

Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-
remitting course. The last decades of intense research uncovered a pathological network of …

Many clinical studies have demonstrated a correlation between psoriasis vulgaris and
dementia, yet this correlation remains controversial. Our study employed the Mendelian …

Background A major issue with the current management of psoriasis is our inability to predict
treatment response. Objective Our aim was to evaluate the ability to use baseline molecular …

T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the
effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or …

Psoriasis vulgaris is the most common form of the four clinical types. However, early
diagnosis of psoriasis vulgaris is difficult due to the lack of effective biomarkers. The aim of …

METHODS We conducted a cross-sectional study with 1014 psoriasis patients recruited from
January to May 2021. Patients were recruited with a cluster survey method in Yueyang …