Membrane proteins and lipids play roles in regulating biological functions of cells. However,
the analysis of interactions between membrane proteins and lipids in biological membranes …

Membrane proteins determine the precise function of each membrane and, therefore, the
function of each cell type. These proteins essential roles in cell physiology, participating in …

AlphaFold2 is a machine-learning based program that predicts a protein structure based on
the amino acid sequence. In this article, we report on the current usages of this new tool and …

Membrane proteins and associated complexes currently comprise the majority of therapeutic
targets and remain among the most challenging classes of proteins for analytical …

We have investigated the nature of the interaction of small organic drug molecules with lipid
membranes of various compositions. Using infrared spectroscopy and differential scanning …

The discovery of allosteric modulators is an emerging paradigm in drug discovery, and
signal transduction is a subtle and dynamic process that is challenging to characterize. We …

The sarco (endo) plasmic reticulum Ca 2+-ATPase (SERCA) plays an essential role in
maintaining the low cytosolic Ca 2+ level that enables a variety of cellular processes …

K-Homology domain (KH domain) proteins bind single-stranded nucleic acids, influence
protein–protein interactions of proteins that harbor them, and are found in all kingdoms of …

The discovery of small-molecule allosteric modulators is an emerging paradigm in drug
discovery, and signal transduction is a subtle and dynamic process that is challenging to …

Many redox diseases, including diabetes, are associated with an imbalance of calcium
homeostasis, regulated mainly by a Ca2+-ATPase pump (SERCA). Dysfunction of this …