Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the
most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and …

Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike
patients with beta (β)-thalassemia major, do not require regular transfusion therapy for …

The complex pathophysiology in β-thalassemia can translate to multiple morbidities that
affect every organ system. Improved survival due to advances in management means that …

Thalassemia syndromes are characterized by the inability to produce normal hemoglobin.
Ineffective erythropoiesis and red cell transfusions are sources of excess iron that the human …

Background—Pulmonary arterial hypertension (PAH) remains a concern in patients with β-
thalassemia major (TM) and intermedia (TI); however, studies evaluating its prevalence and …

Erythroferrone (ERFE) is produced by erythroblasts in response to erythropoietin (EPO) and
acts in the liver to prevent hepcidin stimulation by BMP6. Hepcidin suppression allows for …

The intricate interplay of anemia and iron overload under the pathophysiological umbrella of
ineffective erythropoiesis in non-transfusion-dependent β-thalassemia (NTDT) results in a …

HCC: hepatocellular carcinoma. α/β-globin imbalance leading to clinically-significant
disease). For each patient, data were retrieved for gender, age at last observation, status …

Despite receiving no or only occasional blood transfusions, patients with non‐transfusion‐
dependent thalassemia (NTDT) have increased intestinal iron absorption and can …

Over the past decade, evidence has been mounting on the detrimental clinical sequelae of
untreated anemia in patients with non-transfusion-dependent β-thalassemia (NTDT). There …