Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Mesenchymal stem cells (MSCs) are typically defined by their in vitro characteristics, and as
a consequence the in vivo identity of MSCs and their niches are poorly understood. To …

In this study, we characterized the self-renewal capability, multi-lineage differentiation
capacity, and clonogenic efficiency of human dental pulp stem cells (DPSCs). DPSCs were …

The hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions
during development, and HH signaling continues in discrete populations of cells within …

Stem cells can self-renew and produce different cell types, thus providing new strategies to
regenerate missing tissues and treat diseases. In the field of dentistry, adult mesenchymal …

Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Currently regeneration of tooth and periodontal damage still remains great challenge. Stem
cell‐based tissue engineering raised novel therapeutic strategies for tooth and periodontal …

Tissue homeostasis requires the production of newly differentiated cells from resident adult
stem cells. Central to this process is the expansion of undifferentiated intermediates known …

The dental follicle is an ectomesenchymal tissue surrounding the developing tooth germ. It is
believed that this tissue contains stem cells and lineage committed progenitor cells or …