Mechanisms of estrogen action

S Nilsson, S Makela, E Treuter… - Physiological …, 2001 - journals.physiology.org
Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

The aryl hydrocarbon receptor complex and the control of gene expression

TV Beischlag, JL Morales… - Critical Reviews™ in …, 2008 - dl.begellhouse.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls
the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2, 3, 7, 8 …

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

EFSA Panel on Contaminants in the Food Chain … - Efsa …, 2018 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

EA Stevens, JD Mezrich, CA Bradfield - Immunology, 2009 - Wiley Online Library
The aryl hydrocarbon receptor (AHR) is a protein best known for its role in mediating toxicity.
Over 30 years of research has uncovered additional roles for the AHR in xenobiotic …

Regulation of cytochrome P450 (CYP) genes by nuclear receptors

P Honkakoski, M Negishi - Biochemical Journal, 2000 - portlandpress.com
Members of the nuclear-receptor superfamily mediate crucial physiological functions by
regulating the synthesis of their target genes. Nuclear receptors are usually activated by …

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target

S Safe, SO Lee, UH Jin - Toxicological Sciences, 2013 - academic.oup.com
The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues,
and there is increasing evidence that the AHR plays an important role in cellular …

The Ah receptor: adaptive metabolism, ligand diversity, and the xenokine model

MN Avilla, KMC Malecki, ME Hahn… - Chemical research in …, 2020 - ACS Publications
The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many
important questions about its role in normal physiology and development. Moreover, we still …

Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

S Zhang, C Qin, SH Safe - Environmental health perspectives, 2003 - ehp.niehs.nih.gov
Chemoprotective phytochemicals exhibit multiple activities and interact with several cellular
receptors, including the aryl hydrocarbon (Ah) receptor (AhR). In this study we investigated …

Endocrine disruptors and endometriosis

S Dutta, SK Banu, JA Arosh - Reproductive Toxicology, 2023 - Elsevier
Endometriosis is a hormone-dependent inflammatory gynecological disease of reproductive-
age women. It is clinically and pathologically characterized by the presence of functional …

Inhibitory aryl hydrocarbon receptor− estrogen receptor α cross-talk and mechanisms of action

S Safe, M Wormke - Chemical research in toxicology, 2003 - ACS Publications
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and structurally related halogenated aromatic
compounds are industrial chemicals and combustion byproducts that have been identified in …