Electric‐field‐driven printed 3D highly ordered microstructure with cell feature size promotes the maturation of engineered cardiac tissues

G Zhang, W Li, M Yu, H Huang, Y Wang… - Advanced …, 2023 - Wiley Online Library
Engineered cardiac tissues (ECTs) derived from human induced pluripotent stem cells
(hiPSCs) are viable alternatives for cardiac repair, patient‐specific disease modeling, and …

Extracellular vesicles and microRNAs in the regulation of cardiomyocyte differentiation and proliferation

T Minakawa, JK Yamashita - Archives of Biochemistry and Biophysics, 2023 - Elsevier
Cardiomyocyte differentiation and proliferation are essential processes for the regeneration
of an injured heart. In recent years, there have been several reports highlighting the …

[HTML][HTML] Multifactorial approaches to enhance maturation of human iPSC-derived cardiomyocytes

K Kistamás, A Müller, S Muenthaisong… - Journal of Molecular …, 2023 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS …

X Jiang, J Yang, Y Lin, F Liu, J Tao, W Zhang… - Stem Cell Research & …, 2023 - Springer
Background Acute compartment syndrome (ACS) is one of the most common complications
of musculoskeletal injury, leading to the necrosis and demise of skeletal muscle cells. Our …

Extracellular vesicles from organoid‐derived human retinal progenitor cells prevent lipid overload‐induced retinal pigment epithelium injury by regulating fatty acid …

H Gao, Y Zeng, X Huang, Q Liang, J Xie… - Journal of …, 2024 - Wiley Online Library
Retinal degeneration (RD), a group of diseases leading to irreversible vision loss, is
characterised by retinal pigment epithelium (RPE) or retinal neuron damage and loss. With …

Hypoxic extracellular vesicles from hiPSCs protect cardiomyocytes from oxidative damage by transferring antioxidant proteins and enhancing Akt/Erk/NRF2 signaling

S Bobis-Wozowicz, M Paw, M Sarna… - Cell Communication and …, 2024 - Springer
Background Stem cell-derived extracellular vesicles (EVs) are an emerging class of
therapeutics with excellent biocompatibility, bioactivity and pro-regenerative capacity. One of …

Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell‐derived extracellular vesicles in stirred‐tank bioreactors

MHG Costa, MS Costa, B Painho… - Biotechnology and …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) act as
signaling mediators of cellular responses. However, despite representing a promising …

Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes

M Viola, MP Bebelman, RGC Maas… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as important mediators of intercellular
communication in the heart under homeostatic and pathological conditions, such as …

[HTML][HTML] Microfiber-reinforced hydrogels prolong the release of human induced pluripotent stem cell-derived extracellular vesicles to promote endothelial migration

G Cedillo-Servin, AF Louro, B Gamelas… - Biomaterials …, 2023 - Elsevier
Extracellular vesicle (EV)-based approaches for promoting angiogenesis have shown
promising results. Yet, further development is needed in vehicles that prolong EV exposure …

Extracellular vesicle biogenesis of three‐dimensional human pluripotent stem cells in a novel Vertical‐Wheel bioreactor

L Muok, L Sun, C Esmonde, H Worden… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) secreted by human‐induced pluripotent stem cells (hiPSCs)
have great potential as cell‐free therapies in various diseases, including prevention of blood …