Prostate cancer is the second most common cancer in men in the United States, and racial
disparities are greatly observed in the disease. Specifically, African American (AA) patients …

Conrad Waddington's theory of epigenetic landscape epitomize the process of cell fate and
cellular decision-making during development. Wherein the epigenetic code maintains …

Background Lymphocyte activating 3 (LAG3, LAG-3, CD223) is a promising target for
immune checkpoint inhibition in clear cell renal cell carcinoma (KIRC). The aim of this study …

Recent years have witnessed the groundbreaking success of immune checkpoint blockage
(ICB) in metastasized malignant melanoma. However, biomarkers predicting the response to …

Background DNA methylation of the immune checkpoint gene PD-L1 has recently been
shown to be associated with PD-L1 mRNA expression in various malignancies. This study …

Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize
specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential …

Molecular diagnostics is a rapidly evolving area of surgical pathology, that is gradually
beginning to transform our diagnostical procedures for a variety of tumors. Next to molecular …

Simple Summary Prostate cancer is a heterogeneous disease and a major cause of cancer
deaths worldwide. The most widely used prostate cancer biomarker, prostate-specific …

Simple Summary Prostate cancer is a major cause of cancer-related death in men
worldwide. There is an urgent clinical need for improved prognostic biomarkers to better …

Next to a persistent infection with high-risk human papillomavirus (HPV), molecular changes
are required for the development of cervical cancer. To identify which molecular alterations …