For centuries, philosophers and scientists have been fascinated by the principles and
implications of regeneration in lower vertebrate species. Two features have made zebrafish …

The ability to control pattern formation is critical for the both the embryonic development of
complex structures as well as for the regeneration/repair of damaged or missing tissues and …

Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic
organisms. Although DNA methylation likely has a conserved role in gene silencing, the …

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of
DNA methylation that is highly expressed in many cancers. Here, we use transgenic …

Insulin-producing pancreatic β cells in mice can slowly regenerate from glucagon-producing
α cells in settings like β cell loss, but the basis of this conversion is unknown. Moreover, it …

Modern biomedical research and preclinical pharmaceutical development rely heavily on
the phenotyping of small vertebrate models for various diseases prior to human testing. In …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Chemical modification of nucleotide bases in DNA provides one mechanism for conveying
information in addition to the genetic code. 5-methylcytosine (5mC) represents the most …

The adult zebrafish has the potential to become an important model for diabetes-related
research. To realize this potential, small-scale methods for analyzing pancreas function are …