The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

The maternal-to-zygotic transition (MZT) is one of the most profound and tightly orchestrated
processes during the early life of embryos, yet factors that shape the temporal pattern of …

Here, we provide fundamental insights into early human development by single-cell RNA-
sequencing of human and mouse preimplantation embryos. We elucidate conserved …

We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …

Poly (A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but
difficulties in globally measuring poly (A)-tail lengths have impeded greater understanding of …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Long noncoding RNAs (lncRNAs) comprise a diverse class of transcripts that structurally
resemble mRNAs but do not encode proteins. Recent genome-wide studies in humans and …

methylcytosine is a major epigenetic modification that is sometimes called" the fifth
nucleotide." However, our knowledge of how offspring inherit the DNA methylome from …

After fertilization, maternal factors direct development and trigger zygotic genome activation
(ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …