Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Abstract Iron–sulphur (Fe–S) clusters have long been recognized as essential and versatile
cofactors of proteins involved in catalysis, electron transport and sensing of ambient …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Abstract Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects
lead to severe diseases among which is Friedreich's ataxia caused by impaired expression …

Iron/sulfur centers are key cofactors of proteins intervening in multiple conserved cellular
processes, such as gene expression, DNA repair, RNA modification, central metabolism and …

The mitochondrion is well known for its key role in energy transduction. However, it is less
well appreciated that it is also a focal point of iron metabolism. Iron is needed not only for …

Iron and oxygen share a delicate partnership since both are indispensable for survival, but if
the partnership becomes inadequate, this may rapidly terminate life. Virtually all cell …

The broad range of cellular activities carried out by Fe–S proteins means that they have a
central role in the life of most organisms. At the interface between biology and chemistry …

Abstract Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and
inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with …

Cellular depletion of the human protein frataxin is correlated with the neurodegenerative
disease Friedreich's ataxia and results in the inactivation of Fe− S cluster proteins. Most …